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Food Science / RefWorks Lecture - Curcumin & Prostate Cancer

Lecture given to Food Science class, Spring 2007
Katie Newman
TinyURL for this page: 
tinyurl.com/aa9ahc

  1. Refworks
  2. Develop Search Terminology
  3. Comparison of Retrievals from Several Databases
  4. Resources for Plant Medicinal Research at the University of Illinois
  5. Shared RefWorks Databases
  6. Keep Up-to-date with Autoalerts

I. UIUC RefWorks Support Site

Find here:

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II. Develop Search Terminology

Keep looking for new terms as you perform your search in the various resources. Reiterate the search.

Curcumin

Use MeSH database, a part of PubMed to find alternative words / phrases:

Searched EmTree, a part of Embase, for turmeric and for curcumin.

"Or" both of these terms.

Searched Mosby's Handbook of Herbs & Natural Supplements for turmeric:

Dr. Duke's Phytochemical and Ethnobotanical Databases - Chemicals in Curcuma longa - a long list!

Environmental Chemistry.com:

(1E,4Z,6E)-5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl) hepta-1,4,6-trien-3-one; (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl) hepta-1,6-diene-3,5-dione; 1, 6-Heptadiene-3,5-dione, 1,7-bis (4-hydroxy-3-methoxyphenyl)-; 1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-; 1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-, (1E,6E)-; 1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-, (E,E)-; 1,7-Bis(4-hydroxy-3-methoxyphenyl) hepta-1,6-diene-3,5-dione; 1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione; 1,9-Bis(4-hydroxy-3-methoxyphenyl)-2,7-nonadiene-4,6-dione; 2,7-Nonadiene-4,6-dione, 1,9-bis(4-hydroxy-3-methoxyphenyl)-; Bio1_000405; Bio1_000894; Bio1_001383; C10443; CI 75300; CI Natural Yellow 3; Cucurmin; Curcuma; Curcumin; Curcumin I; Curcumin; 1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione; Diferaloylmethane; Diferuloylmethane; E 100; Gelbwurz; Golden seal; Haidr; Halad; Haldar; Halud; Hydrastis; Indian saffron; Indian turmeric; K00009; Kacha haldi; Kurkumin [Czech]; Merita earth; MLS000069631; Natural yellow 3; NCI60_002883; NCIMech_000700; Orange Root; Safran d'Inde; SDCCGMLS-0066836.P001; SMR000058237; Souchet; Terra Merita; Tumeric yellow; Turmeric; Turmeric (>98% curcurmin) ; Turmeric oleoresin (79%-85% curcumin) ; Turmeric yellow; Yellow Ginger; Yellow puccoon; Yellow Root; Yo-Kin; Zlut prirodni 3 [Czech]; CAS Number for cucurmin is 458-37-7

SciFinder Scholar - Use to find articles in Chemical Abstracts, but also to find synonyms:

1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-, (E,E)- (8CI); Curcumin (6CI); (E,E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione; C Yellow 15; C.I. 75300; C.I. Natural Yellow 3; Curcuma; Curcumin I; Curcumine; Diferuloylmethane; E 100; E 100 (dye); Haidr; Halad; Haldar; Halud; Indian Saffron; Kacha Haldi; Merita Earth; NSC 32982; Natural Yellow 3; San-Ei Curcumine AL; San-Ei Gen Curcumine AL; Souchet; Terra Merita; Turmeric; Turmeric (dye); Turmeric yellow; Ukon; Ukon (dye); Yellow Ginger; Yellow Root; Yo-Kin; trans,trans-Curcumin; CAS Number for cucurmin is 458-37-7

===> Curcumin Terms to search (including frequent misspellings):

Curcumin OR curcuma OR curcuminoid OR cucumin OR tumeric OR turmeric OR tumerin OR turmerin OR demethoxycurcumin OR diferuloylmethane



Prostate Cancer

===> Prostate Cancer Terms to search:

Prostate cancer OR prostatic neoplasm* OR (prostate and (cancer* or neoplasm*)) OR prostate specific antigen OR (prostate and PSA)

 

===> Combination Search: (curcumin terms) AND (prostate terms)

(Curcumin OR curcuma OR curcuminoid OR cucumin OR tumeric OR turmeric OR tumerin OR turmerin OR demethoxycurcumin OR diferuloylmethane) AND (Prostate cancer OR prostatic neoplasm* OR (prostate and (cancer* or neoplasm*)) OR prostate specific antigen OR (prostate and PSA))

 

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III. Comparison of retrievals in Several Databases

Summary for search for articles on the effects of curcumin or turmeric on prostate cancer:

Database Number of citations
PubMed 62

Embase (+ PubMed, de-duplicated)

[Note: In March, 2008, we cancelled our subsciption to EmBase. However, the articles in Embase are all available in a more comprehensive database, Scopus.]

114
Web of Science 90
CAB Abstracts 22
Biological Abstracts 44
SciFinder Scholar (Chemical Abstracts) (+ PubMed, de-duplicated) 114
Food Science & Technology Abstracts (FSTA) 5
SciFinder Scholar and Embase (unique records) ~156
Google Scholar (not all cites are for articles; many are just citing references within articles). 1326 - 1900
CRISP (biomedical grants awarded on curcumin research)  


PubMed Search, (1950s-present): 62 hits

Searched:
(Prostate cancer OR prostatic neoplasm* OR (prostate and (cancer* or neoplasm*)) OR prostate specific antigen OR (prostate and PSA)) AND (Curcumin OR curcuma OR cucurma OR cucumin OR curcuminoid OR tumeric OR turmeric OR tumerin OR turmerin OR demethoxycurcumin OR diferuloylmethane)

 

CAB Abstracts Search, (1910-present): 22 hits

Searched:
("Prostate cancer" OR "prostatic neoplasm*" OR (prostate and (cancer* or neoplasm*)) OR "prostate specific antigen" OR (prostate and PSA)) AND (Curcumin OR curcuma OR cucurma OR cucumin OR curcuminoid OR tumeric OR turmeric OR tumerin OR turmerin OR demethoxycurcumin OR diferuloylmethane)

Note: Use "general search" mode, and formulate search in the Topic search box. Surround phrases in quotation marks.

 

Web of Science Search, (1970-present): 90 hits

Searched:
("Prostate cancer" OR "prostatic neoplasm*" OR (prostate and (cancer* or neoplasm*)) OR "prostate specific antigen" OR (prostate and PSA)) AND (Curcumin OR curcuma OR cucurma OR cucumin OR curcuminoid OR tumeric OR turmeric OR tumerin OR turmerin OR demethoxycurcumin OR diferuloylmethane)

Note: Use "general search" mode, and formulate search in the Topic search box. Surround phrases in quotation marks.

 

Biological Abstracts Search, (1969-present): 44 hits

Searched:
("Prostate cancer" OR "prostatic neoplasm*" OR (prostate and (cancer* or neoplasm*)) OR "prostate specific antigen" OR (prostate and PSA)) AND (Curcumin OR curcuma OR cucurma OR cucumin OR curcuminoid OR tumeric OR turmeric OR tumerin OR turmerin OR demethoxycurcumin OR diferuloylmethane)

Note: Use "general search" mode, and formulate search in the Topic search box. Surround phrases in quotation marks.

 

Food Science & Technology Abstracts (FSTA) Search, (1969-present): 5 hits

Searched:
("Prostate cancer" OR "prostatic neoplasm*" OR (prostate and (cancer* or neoplasm*)) OR "prostate specific antigen" OR (prostate and PSA)) AND (Curcumin OR curcuma OR cucurma OR cucumin OR curcuminoid OR tumeric OR turmeric OR tumerin OR turmerin OR demethoxycurcumin OR diferuloylmethane)

Note: Use "general search" mode, and formulate search in the Topic search box. Surround phrases in quotation marks.

 

SciFinder Scholar (Chemical Abstracts) Search, (1907-present): 114 hits

Searched:
The effect of turmeric or curcumin on prostate cancer

Notes:

 

Google Scholar Search, 1326-1900 hits

Over half may so incomplete as to be useless, and others are duplicates (??)

Searched:
prostate Curcumin | curcuma | cucurma | cucumin | curcuminoid | tumeric | turmeric | tumerin | turmerin | demethoxycurcumin | diferuloylmethane
(which translates to searching the full text for prostate PLUS any one of the curcumin terms)

1900 apparent hits, but when I downloaded them into Zotero (for later export to RefWorks) only 1326 downloaded). Furthermore, many were based on cited references appearing at the end of articles rather than citations to articles themselves.

Note: Google Scholar does not search behind the firewalls of Elsevier (the publisher of nearly 2000 Sci-tech journals) or the American Chemical Society.

To import these into RefWorks, see the instructions. You will want to install the Zotero plugin for the Firefox web browser if you want to download more than one citation from Google Scholar at at time.

 

"Hits" from searching the CRISP database for turmeric or curcumin, 1/31/07:

You had 36 hits for the query: (curcumin | turmeric)

Rank Score Grant Number PI Name Project Title
1 100 1R21AT002945-01A1 ADLER, SHARON Efficacy/mechanisms of curcumin in diabetic nephropathy
2 100 5R01CA109269-02 ANANT, SHRIKANT Dietary Prevention of Cancer
3 100 7R21CA106207-03 BRIGHT, JOHN Curcumin inhibition of growth signaling in leukemia
4 100 5R01AI045555-05 CHAN, MARION NITRIC OXIDE INHIBITOR AND LEISHMANIA PATHOGENESIS
5 100 7R01DK047995-11 CHEN, ANPING Inhibition of hepatic stellate cell activation
6 100 1U01AG028583-01 FRAUTSCHY, SALLY Curcumin and Curcumin Derivatives for Alzheimer's
7 100 5R21CA102516-02 GAUTAM, SUBHASH Curcumin/TRAIL Combination Therapy of Prostae Cancer
8 100 5R01HL073718-04 HOFFMAN, STANLEY PKCepsilon-Related Proteins in Lung Fibrosis
9 100 5R01DK067286-03 KIELA, PAWEL Inflammatory Bowel Disease: A Novel Therapeutic Approach
10 100 1R01CA118947-01 KONG, TONY Chemopreventive Signaling Mechanisms in Prostate Cancer
11 100 3R01CA118947-01S1 KONG, TONY Chemopreventive Signaling Mechanisms in Prostate Cancer
12 100 5R01CA104922-02 KOUMENIS, CONSTANTINOS Phenolic antioxidants as tumor radio/chemosensitizers
13 100 5R21CA104337-02 KURZROCK, RAZELLE Exploratory Trial of Curcumin in Pancreatic Cancer
14 100 5R21CA100622-02 PONNAPPA, BIDDANDA Cell-type specific targting of curcumin
15 100 5R21CA107217-02 VADHAN-RAJ, SAROJ Curcumin/Bioperine in Multiple Myeloma
16 100 1F31AT003973-01 VOLAK, LAURIE Curcumin-piperine interaction with CYP3A, UGT, and SULT enzymes.
17 96 1R21AT003614-01 FUNK, JANET Efficacy of Turmeric Extract in Prevention of Post-menopausal Osteoporosis
18 90 1R21AG027794-01A1 ORLANDO, ROBERT Curcumin-based analogs as improved inhibitors of Abeta aggregation
19 75 1K07CA111653-01A2 LAO, CHRISTOPHER Development of a Melanoma Chemoprevention Model
20 60 1R01CA122394-01 KATDARE, MEENA APC mutation and breast cancer: Prevention by curcumin
21 45 1R03CA121403-01 COOK, THOMAS Mechanistic Studies on the Disposition of Farnesol with Single and Multiple Dosin
22 45 1R21CA119189-01A1 DORAI, THAMBI CURCUMIN AS AN INHIBITOR OF PROSTATE CANCER BONE METASTASIS
23 45 5R03CA119295-02 STATES, J Effects of chemopreventive agents on DNA damage response
24 30 5R01AR047314-05 PAVLATH, GRACE Molecular Physiology of Recovery from Muscle Atrophy
25 16 5P50AT002779-02 CASSILETH, BARRIE MSKCC Research Center for Botanical Immunomodulators
26 16 5P50AT000474-05 FUNK, JANET ARIZONA CENTER FOR PHYTOMEDICINE RESEARCH (ACPRX)
27 16 1R43AT004118-01 RAMANUJAM, RAMA URINALYSIS FOR PATIENT COMPLIANCE TO CAM THERAPY
28 15 5R21CA118111-02 CHRISTOFIDOU-SOLOMIDOU, MELPO Use of Curcumin and Flaxsseed in Radiation Pneumonopathy
29 15 5P50AG016570-080005 COLE, GREGORY OXIDATIVE DAMAGE TO SYNAPTIC COMPARTMENTS IN AD
30 15 3P50AG016570-08S10005 COLE, GREGORY OXIDATIVE DAMAGE TO SYNAPTIC COMPARTMENTS IN AD
31 15 5R01AT003008-02 COLE, GREGORY Can Omega 3 fatty acids Slow Alzheimer Pathogensis?
32 15 1R01CA118560-01A1 FONG, LOUISE Chemoprevention of upper aerodigestive tract cancer by dietary zinc
33 15 5R01AG021975-03 FRAUTSCHY, SALLY Human tau neurodegeneration in Alzheimer's
34 15 1U01AG028526-01 KLUNK, WILLIAM Amyloid-Lowering Small Molecule AB-Binding Agents in AD
35 15 5R01CA017625-29 LEE, KUO-HSIUNG PLANT ANTITUMOR AGENTS
36 15 5R01CA114264-02 SINGH, POMILA Growth Factors, Curcumin and Colon Carcinogenesis

 

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IV. Resources for Plant Medicinal Research at the University of Illinois

A website that lists in one place many of the resources at UIUC folks doing plant medicinal research will find useful. Other resource to try include:

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V. Shared RefWorks databases

You may export these citations into your own RefWorks account!

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VI. Keep up to Date! Set up Auto-alerts

Have your searches run in a database automatically, whenever the database is updated, and the results sent to you via e-mail!   Use auto-alerts to keep up-to-date on the research in a particular area, keep track of your colleagues’ research, or to receive the table of contents of selected publications.  (Note: these instructions are also in the Biotech FAQ, pg. 3.) pdf

Auto-alerts from Web of Science

Since Web of Science is multidisciplinary, covering all the major journals in most disciplines, and is updated weekly, this is a terrific service!  To set up an alert in Web of Science:

First, you must "register":

After you have logged in, you're ready to set up an alert:

Auto-alerts from PubMed, GenBank, or other NCBI resources

Recently it became possible to set up auto-alerts to run against the NCBI resources such as GenBank and PubMedPubMed is most likely the one you’ll want to use to set up an alert, so you’ll be notified of new articles in your subject area, or written by particular scientists.

First, you must “register” :

After you have logged in, you’re ready to set up an alert:

Publisher-based Auto-alerts 

Several publishers and journals also allow you to set up “auto-alerts” for their journals, so you get the results as soon as the new issue of the journal is posted – much faster than the articles appear in indexes such as Current Contents, Web of Science, PubMed, etc.!  Among the most popular sites for this are:

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