These letters and reports were written to the secretary of the American Home Missionary Society by Presbyterian and Congregational ministers and agents. They discuss social, economic, and educational issues in Illinois, Indiana, Missouri, and Michigan. Some notable Illinois correspondents include Stephen Bliss, John Ellis, Thomas Lippincott, B. Y. Messenger, and John Mason Peck.
The Society's work in Illinois, Indiana, and Missouri is documented by 2,032 items (photostats), for which there is a chronological card calendar. Reports from Michigan are available on microfilm and calendared in Necia Ann Musser, "Home Missionaries on the Michigan Frontier, 1825-1846," 3 volume. (Ph.D. diss., University of Michigan, 1967).
The originals of the entire American Home Missionary Society collection went to the Amistad Research Center, Tulane University, in the 1970s.